Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection
نویسندگان
چکیده
منابع مشابه
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection.
BACKGROUND Acute aortic dissection (AAD) is a life-threatening vascular disease without effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated in the development of chronic vascular diseases including aneurysm, but the key effectors and mechanism of action remain unknown. To define further the role of MMPs in AAD, we screened circulating MMPs in AAD patients, and then...
متن کاملNeutrophil - Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection Running title :
Ad Addr dres ess s fo for r Co Co C rr rres espo pond nden ence ce: : Abstract: BackgroundʊAcute aortic dissection (AAD) is a life-threatening vascular disease without
متن کاملRole of neutrophil-derived matrix metalloproteinase-9 in tissue regeneration.
Ischemic tissue regeneration depends on neovascularization, the growth of new blood vessels. Bone marrow (BM)-derived cells, including neutrophils, have been shown to contribute to neovascularization during hind limb ischemia and inflammation. Neutrophils produce a broad array of angiogenic growth factors and proteases, which promote remodeling of arterioles into arteries through proteolytic me...
متن کاملExpression of matrix metalloproteinase-12 in aortic dissection
BACKGROUND Aortic dissection(AD) is an acute process of large blood vessels characterized by dangerous pathogenic conditions and high disability and high mortality. The pathogenesis of AD remains debated. Matrix metalloproteinase-12 (MMP-12) participates in many pathological processes such as abdominal aortic aneurysm, atherosclerosis, emphysema and cancer. However, this elastase has rarely bee...
متن کاملRule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department
INTRODUCTION Matrix metalloproteinases (MMPs) are involved in aortic pathophysiology. Preliminary studies have detected increased plasma levels of MMP8 and MMP9 in patients with acute aortic dissection (AAD). However, the performance of plasma MMP8 and MMP9 for the diagnosis of AAD in the emergency department is at present unknown. METHODS The levels of MMP8 and MMP9 were measured by ELISA on...
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ژورنال
عنوان ژورنال: Circulation
سال: 2012
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.112.097097